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Multiple Myeloma (Myeloma Cancer)

Personalised treatments designed to fight cancer while minimising side effects.

What is Multiple Myeloma?

Multiple myeloma, also known as myeloma cancer, is a type of blood cancer that develops in plasma cells – a kind of white blood cell found in the bone marrow. Healthy plasma cells help fight infections by making antibodies, but in multiple myeloma, abnormal plasma cells grow uncontrollably. These cancerous cells crowd out normal blood cells, produce abnormal proteins, and can damage the bones, kidneys, and immune system.

Clinical representation of Multiple Myeloma - OncoCare Malaysia
Clinical representation of Multiple Myeloma - OncoCare Malaysia

How Common is Multiple Myeloma in Malaysia?

According to GLOBOCAN 2020, multiple myeloma accounted for over 600 new cases and more than 400 deaths in Malaysia that year. While it is less common than other cancers such as breast or lung cancer, its impact is significant because it often affects multiple organs and requires specialised, long-term management. Multiple myeloma is typically diagnosed in older adults, but younger patients can also be affected.

What Are the Signs and Symptoms of Multiple Myeloma?

Early stages may not cause obvious symptoms. As the disease progresses, common signs include:
Because these symptoms can overlap with other conditions, proper diagnosis is essential.

How is Multiple Myeloma Diagnosed?

Diagnosis involves a combination of blood tests, urine tests, bone marrow biopsy, and imaging scans. These help to detect abnormal proteins (M-protein or light chains), assess kidney and bone health, and determine the extent of the disease.

Clinical representation of Multiple Myeloma - OncoCare Malaysia

What Are the Causes and Risk Factors of Multiple Myeloma?

The exact cause is unknown, but several factors increase risk:

  • Age: Most patients are over 60 years old
  • Gender: Slightly more common in men
  • Family history: Having a close relative with myeloma or other plasma cell disorders
  • Pre-existing conditions: Such as monoclonal gammopathy of undetermined significance (MGUS)
  • Environmental factors: Exposure to radiation, certain chemicals, or toxins may play a role
Hone Section for Radiotherapy at OncoCare
Clinical representation of Multiple Myeloma - OncoCare Malaysia

What Are the Types of Multiple Myeloma?

Smouldering Myeloma

An early form with no symptoms but abnormal cells are present

Symptomatic disease that requires treatment

When the cancer returns after treatment or does not respond to standard therapies

Clinical representation of Multiple Myeloma - OncoCare Malaysia

What Are the Stages of Multiple Myeloma?

Staging is based on blood markers and the extent of organ involvement:

Stage I

Early disease with lower levels of abnormal proteins and minimal organ damage

Intermediate stage

Advanced disease, with high levels of abnormal proteins, extensive bone damage, or severe complications such as kidney failure

What are the Treatments for Multiple Myeloma?

Multiple myeloma is not yet considered curable, but effective treatments can control the disease, reduce symptoms, and improve survival. Treatment is highly personalised and may include:

Steroids

Often used in combination with other drugs to reduce inflammation and kill myeloma cells.

Stem Cell Transplant

For eligible patients, high-dose chemotherapy followed by a stem cell transplant can offer longer remission.

With advances in therapy, many patients live significantly longer and with better quality of life.

Meet Our Doctors

At OncoCare Malaysia, our multidisciplinary team includes oncologists specialising in blood cancers, haematologists with expertise in bone marrow disorders and transplants, radiation oncologists, radiologists, pathologists, and specialised oncology nurses. Allied health professionals such as nutritionists, physiotherapists, and counsellors also support patients through their journey. Together, we provide comprehensive and personalised care for every patient.

Photo Dr Yap Beng Khiong for Colorectal Colon Cancer at OncoCare
Dr Ben Yap Beng Khiong
叶明强医生
Consultant Clinical Oncologist
Dr John Low for at OncoCare
Dr John Low Seng Hooi
刘胜辉医生
Consultant Clinical Oncologist
Dr M
Dr Matin Mellor Abdullah
Consultant Clinical Oncologist
Photo Dr Yugarajah Asokumaran for at OncoCare
Dr Yugarajah Asokumaran
Consultant Medical Oncologist